Nexus of Pathophysiology & Therapeutics Journal (NPT)
This is the official journal for mechanistic pathophysiology and translational therapeutic research, and a leading journal advancing the mechanistic understanding of disease and translating molecular and cellular insights into therapeutic innovation and precision medicine.
Peer Review Process

Peer Review Process

Nexus of Pathophysiology & Therapeutics (NPT) is committed to a rigorous, transparent, and timely peer-review process, ensuring the highest standards of scientific quality, methodological integrity, and mechanistic insight.

1. Initial Editorial Screening

Upon submission, all manuscripts undergo an initial assessment by the editorial office to evaluate:

  • Alignment with the journal’s scope and focus on mechanistic and translational research
  • Compliance with ethical and reporting standards
  • Minimum methodological quality

Manuscripts that do not meet these criteria may be returned to authors without external review.

2. Peer Review Model

NPT employs a double-blind peer-review system, in which both authors and reviewers remain anonymous to ensure impartial evaluation and minimize bias.

3. Reviewer Assignment

Each manuscript is reviewed by at least two independent experts with relevant subject-area expertise. For complex, multidisciplinary, or highly mechanistic studies, additional reviewers may be invited to assess specific experimental, computational, or translational components.

4. Review Timelines

The standard peer-review period is approximately 5–6 weeks, although timelines may vary depending on:

  • Reviewer availability
  • Manuscript complexity
  • Need for additional rounds of review

5. Editorial Oversight

Section Editors oversee the peer-review process, including:

  • Reviewer selection and invitation
  • Evaluation of reviewer reports
  • Synthesis of recommendations

Final publication decisions are made exclusively by the Editor-in-Chief, taking into account reviewer feedback and editorial judgment.

6. Evaluation Criteria

Manuscripts are assessed based on:

  • Mechanistic depth and causal insight
  • Scientific rigor and methodological robustness
  • Originality and novelty
  • Clarity of data interpretation and reporting
  • Translational or therapeutic relevance

Additional considerations for specific study types include:

  • In vivo and experimental studies: Experimental design, reproducibility, and mechanistic validity
  • Clinical and translational studies: Biological plausibility, mechanistic endpoints, and clinical relevance
  • Computational and systems biology studies: Model validity, transparency, and biological interpretability
  • Diagnostic and biomarker studies: Methodological rigor and translational applicability

7. Confidentiality and Ethical Standards

All manuscripts are treated as strictly confidential. Reviewers must declare any potential conflicts of interest and must not use, share, or disclose manuscript content beyond the purpose of peer evaluation.

8. Revision and Re-Review

Revised manuscripts are typically re-evaluated by the original reviewers to ensure that all comments and concerns have been adequately addressed. Multiple rounds of revision may be requested to ensure scientific rigor and mechanistic robustness.

Commitment to Quality

NPT is dedicated to maintaining a fair, unbiased, and efficient peer-review process. This ensures authors receive constructive feedback while upholding the journal’s mission of publishing high-quality mechanistic and translational research that advances biomedical science and therapeutic discovery.