Nexus of Pathophysiology and Therapeutics (NPT) is an international, peer-reviewed journal publishing research in pathophysiology, biomedical sciences, pharmacology, and therapeutics, with a focus on disease mechanisms and clinical applications.
Nexus of Pathophysiology and Therapeutics (NPT) is an international, peer-reviewed, open-access journal dedicated to advancing knowledge across biomedical, pharmacological, diagnostic, and therapeutic sciences. The journal aims to bridge fundamental disease biology and pathophysiology with clinically relevant research, therapeutic development, and translational applications.
NPT also considers emerging biomedical technologies, molecular approaches, and therapeutic platforms when they provide clear relevance to disease mechanisms, diagnosis, prognosis, prevention, or treatment.
NPT welcomes high-quality research addressing the mechanisms, characterization, diagnosis, progression, prevention, and treatment of human diseases and relevant experimental models, as well as the development and evaluation of therapeutic strategies and biomedical interventions.
The journal particularly welcomes research in the following areas:
Clinical and translational studies that connect biomedical discoveries with diagnosis, prognosis, prevention, or treatment, including research that facilitates the translation of mechanistic and experimental findings into clinically relevant applications.
Diagnostic biomarkers, prognostic markers, disease monitoring, prediction of treatment response, and clinically relevant diagnostic approaches, including molecular, biochemical, laboratory, and imaging-based investigations.
Molecular, cellular, physiological, and pathological processes underlying disease development and progression, including mechanisms of disease initiation, tissue injury, adaptation, repair, and therapeutic response.
Experimental and clinical pharmacology, pharmacodynamics, pharmacokinetics, pharmacotherapy, therapeutic interventions, treatment response, treatment optimization, drug mechanisms, and pharmacological modulation of disease pathways.
Immune mechanisms, inflammatory pathways, host–pathogen interactions, infectious disease biology, and therapeutic approaches to infectious, inflammatory, and immune-mediated disorders.
Experimental and clinical toxicology, adverse drug reactions, drug-induced organ injury, safety assessment, and the mechanisms, biomarkers, prevention, and management of treatment-related toxicity.
Natural products, medicinal plants, bioactive compounds, phytochemistry, phytopharmacology, herbal medicines, and therapeutic modulation of disease-related pathways.
NPT considers experimental, clinical, translational, prospective, retrospective, and observational studies, provided that they address a meaningful biomedical, diagnostic, prognostic, pharmacological, therapeutic, or disease-related scientific question. Analytical epidemiological studies may also be considered when they provide clinically or biologically relevant insights into disease risk, severity, progression, diagnosis, prognosis, or treatment.
The journal welcomes contributions from medicine, pharmacy, pharmacology, biomedical sciences, laboratory sciences, biochemistry, molecular biology, biotechnology, natural products, toxicology, oncology, and related disciplines.
NPT publishes the following article types:
Original Research Articles — including experimental, clinical, translational, prospective, retrospective, and observational studies.
Systematic Reviews and Meta-analyses
Narrative Reviews
Short Communications
Brief Reports
Methodological Studies
Research Protocols
Perspectives
Commentaries
Editorials