Nexus of Pathophysiology and Therapeutics (NPT) is an international, peer-reviewed, open-access journal dedicated to advancing knowledge across biomedical, pharmacological, diagnostic, and therapeutic sciences. The journal aims to bridge fundamental disease biology and pathophysiology with clinically relevant research, therapeutic development, and translational applications.
NPT welcomes high-quality research addressing the mechanisms, characterization, diagnosis, progression, prevention, and treatment of human diseases, as well as the development and evaluation of therapeutic strategies and biomedical interventions.
The journal particularly welcomes research in the following areas:
Clinical and Translational Research: clinical and translational studies that connect biomedical discoveries with diagnosis, prognosis, prevention, or treatment.
Diagnostics, Biomarkers, and Prognostic Research: diagnostic biomarkers, prognostic markers, disease monitoring, prediction of treatment response, and clinically relevant diagnostic approaches.
Laboratory and Biomedical Sciences: clinical laboratory sciences, laboratory medicine, clinical biochemistry, hematology, immunology, molecular diagnostics, and disease-associated biochemical and molecular alterations.
Immunology, Inflammation, and Infectious Diseases: immune mechanisms, inflammatory pathways, host–pathogen interactions, infectious disease biology, and therapeutic approaches to infectious and inflammatory disorders.
Pharmacology and Therapeutics: experimental and clinical pharmacology, pharmacodynamics, pharmacokinetics, pharmacotherapy, therapeutic interventions, treatment response, and treatment optimization.
Nutrition and Nutritional Sciences: clinical nutrition, nutritional biochemistry, nutrition-related diseases, nutraceuticals, nutritional interventions, nutritional biomarkers, nutrigenomics, and the therapeutic effects of nutritional modulation.
Pharmaceutical Sciences: pharmaceutics, pharmaceutical technology, pharmaceutical biotechnology, biopharmaceutics, pharmaceutical analysis, pharmaceutical formulation, drug delivery, controlled and targeted release, nanomedicine, and related pharmaceutical research.
Pathophysiology and Disease Biology: molecular, cellular, physiological, and pathological processes underlying disease development and progression.
Natural Products and Herbal Medicine: pharmacognosy, medicinal plants, phytochemistry, natural products, ethnopharmacology, phytopharmacology, herbal medicines, bioactive compounds, and the development of natural therapeutic agents.
Biochemistry and Molecular Biology: biochemical pathways, molecular targets, signaling pathways, gene and protein regulation, and molecular alterations associated with disease and therapeutic responses.
Medicinal Chemistry and Drug Discovery: drug design and discovery, structure–activity relationships, lead optimization, therapeutic compounds, molecular targets, computational drug discovery, and cheminformatics.
Toxicology and Drug Safety: experimental and clinical toxicology, adverse drug reactions, drug-induced organ injury, safety assessment, and the mechanisms and prevention of treatment-related toxicity.
Cancer Biology and Oncology: cancer pathophysiology, molecular oncology, biomarkers, anticancer pharmacology, therapeutic strategies, and treatment response.
Biotechnology and Advanced Biomedical Sciences: medical and pharmaceutical biotechnology, gene and cell-based therapies, RNA-based therapeutics, stem cells, regenerative medicine, tissue engineering, biomaterials, nanotechnology, and other emerging biomedical technologies with therapeutic or disease-related applications.
NPT considers experimental, clinical, translational, prospective, retrospective, and observational studies, provided that they address a meaningful biomedical, diagnostic, prognostic, pharmacological, therapeutic, or disease-related scientific question. Analytical epidemiological studies may also be considered when they provide clinically or biologically relevant insights into disease risk, severity, progression, diagnosis, prognosis, or treatment.
The journal welcomes contributions from medicine, pharmacy, pharmacology, biomedical sciences, laboratory sciences, biochemistry, molecular biology, pharmaceutical sciences, medicinal chemistry, biotechnology, nutrition, natural products, toxicology, and related disciplines.
NPT publishes Original Research Articles, Clinical and Translational Research, Mechanistic and Experimental Studies, Systematic Reviews and Meta-analyses, Narrative Reviews, Short Communications, Brief Reports, Methodological Studies, Research Protocols, Perspectives, Commentaries, and Editorials.
