Nexus of Pathophysiology & Therapeutics Journal (NPT) is a peer-reviewed, open-access journal committed to advancing mechanistic understanding of disease biology and translating these insights into therapeutic innovation.
The journal publishes high-quality research elucidating molecular, cellular, tissue, and systems-level mechanisms underlying disease processes and therapeutic responses. NPT emphasizes studies that provide causal and mechanistic insight, moving beyond descriptive observations toward explanatory and translational biology.
NPT serves as a platform for integrating experimental, computational, and clinical research, bridging the continuum from fundamental discovery to therapeutic application.
NPT publishes original research across the full spectrum of mechanistic and translational biomedical science, including:
Pharmacology & Therapeutic Mechanisms
Pharmacodynamics, pharmacokinetics, mechanisms of drug action, therapeutic target validation, and the development of novel pharmacological or biological interventions.
Molecular & Cellular Pathophysiology
Molecular and cellular mechanisms underlying disease initiation and progression, including signaling pathways, gene regulation, cellular stress responses, and disease-associated molecular alterations.
Clinical and Translational Mechanistic Studies
Mechanistic clinical investigations evaluating biological pathways, therapeutic target engagement, pharmacodynamic responses, biomarker dynamics, or mechanistic heterogeneity in patient populations. Welcomes early-phase clinical studies, mechanistic clinical trials, and observational clinical investigations with clearly defined mechanistic endpoints and translational relevance.
Translational Pathophysiology & Experimental Medicine
Studies bridging basic biological discoveries with clinical relevance, including in vivo experimental models, disease modeling, translational investigations, and therapeutic target validation.
Therapeutic Innovation & Biomedical Engineering
Medical device development and mechanistic validation; surgical and interventional innovation with mechanistic rationale; drug delivery systems and formulation science; AI/ML tools with biological or pharmacological interpretability; diagnostic technology development linked to disease mechanisms; experimental prototypes bridging laboratory discovery to clinical application.
Immunopathology & Inflammatory Mechanisms
Immune-mediated disease mechanisms, inflammatory signaling pathways, immune dysregulation, and immune-targeted therapeutic strategies.
Systems Biology, Omics & Precision Medicine
Systems biology approaches, multi-omics analyses, biomarker discovery, computational modeling, and precision medicine strategies with mechanistic or therapeutic relevance.
Disease-Focused Mechanistic Research
Mechanistic investigations in specific disease domains such as oncology, cardiovascular disease, neurodegenerative disorders, metabolic diseases, and infectious diseases.
Mechanistic Reviews
Comprehensive synthesis-driven reviews integrating current evidence on molecular, cellular, systems-level, and translational mechanisms. These articles emphasize mechanistic interpretation, highlight conceptual frameworks, identify knowledge gaps, and propose emerging directions in mechanistic and therapeutic biology.
Guidelines & Expert Consensus Statements
Authoritative methodological or mechanistic guidelines, expert consensus statements, experimental best-practice frameworks, and standardization approaches relevant to pathophysiology, experimental therapeutics, laboratory models, or mechanistic methodology.
Commentary & Perspectives
Short, viewpoint-driven articles offering expert insight on emerging mechanistic concepts, novel therapeutic paradigms, significant findings, conceptual debates, or forward-looking perspectives relevant to pathophysiology and therapeutics.
Study Protocols
Detailed, pre-specified methodological frameworks outlining planned mechanistic, experimental, translational, or preclinical studies. Protocols describe the scientific rationale, mechanistic hypotheses, study design, experimental workflows, analytical strategies, and predefined outcomes prior to data collection or analysis. Emphasis is placed on transparency, reproducibility, and mechanistic clarity.
All submissions are expected to provide clear mechanistic interpretation and demonstrate relevance to disease biology or therapeutic processes.
The journal covers major biomedical domains, including:
Studies in other biomedical areas are also considered when aligned with the journal’s mechanistic focus.
NPT prioritizes manuscripts that:
NPT welcomes studies across the full spectrum of biomedical research, including investigations focused on disease pathophysiology, therapeutic mechanisms, experimental models, translational studies, and clinical research.
Manuscripts are evaluated based on their ability to provide biological interpretation, mechanistic insight, or contextual relevance to disease processes or therapeutic action, even if findings are primarily descriptive in nature.
All submissions must provide appropriate mechanistic or translational insight relevant to the article type.
NPT is designed for researchers who aim not only to describe biological phenomena, but to explain them mechanistically and translate this understanding into therapeutic advancement.
